Ultrastructure of Adenovirus Keratitis

Role of MyD88 in Adenovirus Keratitis

Pattern recognition receptors (PRRs) are critical to the early detection and innate immune responses to pathogens. In particular, the toll-like receptor (TLR) system and its associated adaptor proteins have essential roles in early host responses to infection. Epidemic keratoconjunctivitis, caused by the human adenovirus, is a severe ocular surface infection associated with corneal inflammation...

Cytopathology of adenovirus keratitis by replica technique.

Corneal replicas were made from the severely affected eyes of 12 patients presenting with typical signs and symptoms of epidemic keratoconjunctivitis. Adenovirus was isolated from the eyes. Histopathological study of the replicas and cytology of diseased cells removed with the replica showed diffuse mild oedema of the epithelium, with scattered moderately swollen and deformed cells. The clinica...

Adenovirus keratitis: a role for interleukin-8.

PURPOSE Adenovirus type 19 (Ad19) infection of the human cornea results in a chronic, multifocal, subepithelial keratitis. Existing evidence suggests that early subepithelial corneal infiltrates are composed of polymorphonuclear neutrophils. In this study, the capacity of Ad19-infected human corneal stromal fibroblasts (HCFs) to produce neutrophil chemotactants (chemokines) was tested. METHOD...

Adenovirus type 37 keratitis in the C57BL/6J mouse.

PURPOSE To develop a mouse model of adenoviral keratitis that will allow further study of viral and host pathogenic mechanisms. METHODS Corneas of C57BL/6J mice were injected with adenovirus type 37 (Ad37) or virus-free dialysis buffer by a gas-powered microinjection system coupled to a glass micropipette needle. Mouse corneas were examined for signs of inflammation, by clinical examination, ...

Equine keratitis and the possible involvement of equine adenovirus type 1 (EAdV1) and type 2 (EAdV2)